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home > abstract > Griffin, Piper, Daugherty et al.
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Griffin MR, Piper JM, Daugherty JR
et al.
Annals of Internal Medicine, 1991;114:257-263.
A case control study was conducted
among Tennessee Medicaid patients over the age of 65 to
evaluate the risk of peptic ulcer disease associated with
the use of nonaspirin nonsteroidal anti-inflammatory medications.
Included in the study were 1,415 patients who had been
hospitalized for either peptic ulcer disease or upper
gastrointestinal hemorrhage. The control group consisted
of 7,063 other Medicaid patients. Results of this study
showed that patients taking prescription nonaspirin nonsteroidal
anti-inflammatories were four times more likely to be
hospitalized for peptic ulcer disease or upper gastrointestinal
hemorrhage than non-users. The risk of developing ulcer
disease increased with increased doses with the risk being
the greatest during the first month of treatment.
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