ESR and CRP are relatively non-specific indicators of inflammation. Their lack of sensitivity and specificity limits their value in patient assessment at the time of presentation where the clinical features of inflammation are of more value than the laboratory tests. Nonetheless, both tests can be helpful in monitoring the progress of an inflammatory disease such as rheumatoid arthritis and have particular value in elderly patients where polymyalgia rheumatica is suspected. Mild elevation of ESR and CRP is common, particularly in the elderly, and should not in the absence of clinical indicators be an indication for further investigations.

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