The lack of systemic symptoms (no fever, fatigue or malaise) would make a diagnosis of seronegative arthritis more likely.

Alarm features include fever, redness of the joint that is painful with very limited movement.

Trauma is not supported by the history and the wrist joint is an unusual location for single joint OA.

Tactful probing questions are appropriate to determine the risk of an STD as a cause of Reiter's syndrome. The sort of question that might be helpful in this situation is: Occasionally this type of problem can occur when you have a new partner. Are you in a mutually monogamous relationship?

Seronegative arthritis includes Reiter's syndrome, psoriatic arthritis and IBD-associated arthritis.